Hyperbaric Oxygen Therapy (HBOT) Resources

As a certified HBOT provider, I stay up-to-date with the latest HBOT research so you can make informed choices about your wellness journey. 

Curious to dive deeper into the science behind HBOT? Below are trusted studies and articles exploring how this therapy supports healing, recovery, and overall wellness.

🔬 HBOT Mechanism

• Mechanism and Prevention of Hyperbaric Oxygen Convulsions (Groborz et al., 2024)
  Explores how high oxygen pressure can cause seizures and possible prevention strategies.

• A General Overview on HBOT: Applications, Mechanisms and Translational Opportunities (Medicina, 2021)
  A detailed overview of how HBOT works, approved uses (like wound healing and infections), and emerging opportunities.

• Bhutani S, Vishwanath G. Hyperbaric oxygen and wound healing. Indian J Plast Surg. 2012.

• Thom SR. Hyperbaric oxygen: its mechanisms and efficacy. Plast Reconstr Surg. 2011.

• Thom SR. Oxidative stress is fundamental to hyperbaric oxygen therapy. J Appl Physiol. 2009.

• Wingelaar TT, Brinkman P, van Ooij PJAM, et al. Markers of Pulmonary Oxygen Toxicity in HBOT Using Exhaled Breath Analysis. Front Physiol. 2019.

• Gill A.L., Bell C.N.A. Hyperbaric oxygen: its uses, mechanisms of action, and outcomes. QJM. 2004.

🧩 HBOT and Autism

• Rossignol DA, Rossignol LW, Smith S, et al. HBOT for children with autism: a randomized, controlled trial. BMC Pediatr. 2009.
  
• Rossignol DA, Rossignol LW. HBOT may improve symptoms in autistic children. Med Hypotheses. 2006.
• Rossignol DA, Frye RE. Oxidative stress, mitochondrial dysfunction, and inflammation in autism + HBOT evidence. Front Physiol. 2014.

🧠 HBOT and Dementia / Alzheimer’s

• Harch PG, Fogarty EF. HBOT for Alzheimer’s dementia with PET imaging: a case report. Med Gas Res. 2019.

• Shapira R, Efrati S, Ashery U. HBOT as a new treatment approach for Alzheimer’s disease. Neural Regen Res. 2018.
  

🎗️ HBOT and Cancer 

• Iyikesici M, Slocum A, Slocum A, et al. Efficacy of chemotherapy + keto diet + HBOT in stage IV breast cancer. Cureus. 2017.

• Poff AM, Ari C, Seyfried TN, et al. Keto diet and HBOT prolong survival in metastatic cancer. PLoS One. 2013.

• Seyfried TN, Mukherjee P. Nutritional metabolic therapies for cancer. Nutr Metab (Lond). 2005.

• Vander Heiden MG, Cantley LC, Thompson CB. The Warburg effect: metabolic requirements of cell proliferation. Science. 2009.

• Moen I, Stuhr LE. HBOT and cancer: a review. Target Oncol. 2012.

• Thom SR, Bhopale VM, Yang M. HBOT inhibits microparticle-induced vascular injury in mice. J Appl Physiol.

🧠 HBOT and Stroke

• Rosario ER, Kaplan SE, Khonsari S, et al. HBOT for ischemic stroke: functional & clinical implications. Neurol Res Int. 2018.

• Ostrowski RP, Stepien K, Pucko E, Matyja E. Efficacy of HBOT in hemorrhagic stroke: experimental & clinical. Arch Med Sci. 2017.

• Efrati S, Fishlev G, Bechor Y, et al. HBOT induces late neuroplasticity in post-stroke patients. PLoS One. 2013.

🔋 HBOT and Mitochondria

• Fosen KM, Thom SR. HBOT, vasculogenic stem cells, and wound healing. Antioxid Redox Signal. 2014.
• Palzur E, Zaaroor M, Vlodavsky E, et al. HBOT protects brain mitochondria after injury. Brain Res. 2008.
• Dave KR, Prado R, Busto R, et al. HBOT protects against mitochondrial dysfunction & delays motor neuron disease onset. Neuroscience. 2003.

• Therapeutic Effects of Hyperbaric Oxygen: An Integrated Review (Sen et al., 2021)
  Summarizes HBOT’s effects on circulation, oxygenation, immune health, and tissue repair.

• Hyperbaric Oxygen Therapy as a Neuromodulatory Technique (Frontiers in Neurology, 2024)
  Explores HBOT’s impact on the brain, with applications in TBI, PTSD, fibromyalgia, and cognitive recovery.

• Long-term Outcomes of HBOT in Post-COVID Condition (Scientific Reports, 2024)
  Found lasting improvements in sleep, mood, and quality of life one year after HBOT in Long COVID patients.

• Efficacy and Safety of HBOT for Fibromyalgia (BMJ Open, 2023)
  A randomized trial showing improvements in pain and function for fibromyalgia patients.

• HBOT and Inflammatory Bowel Disease (IBD) (Review, 2024)
  Looks at experimental and clinical trials exploring HBOT’s potential role in gut and autoimmune health.

• HBOT for Healthy Aging (Fu et al., 2022)
  Discusses HBOT’s role in reducing markers of cellular aging and supporting longevity.

• Future Prospects in Regenerative Therapy and Anti-Aging (Frontiers in Aging, 2024)
  Reviews how HBOT supports regeneration, collagen formation, and anti-senescence pathways.

• Clinical Trial: HBOT Dosing Study on Epigenetic Aging & Inflammation (Ongoing)
  Aims to discover how different HBOT pressures and protocols affect biological aging markers.

• Contemporary National Outcomes of HBOT in Necrotizing Soft Tissue Infections (Toppen et al., 2024)
  Analysis of 60,000+ patients: HBOT lowered mortality, reduced amputations, and improved discharge outcomes.

• Adverse Effects of HBOT: A Systematic Review (Frontiers in Medicine, 2023)
  Discusses side effects (ear discomfort, vision changes, oxygen toxicity) and how risks vary with session dose.